Posts tagged "antibodies"

Autism Linked To Gluten Consumption

The cause of autism is still yet to be known, as well as other related behavioral disorders.  However, something useful has been identified by a new study published in the open-access journal PLoS One.

Scientists from Columbia University in New York learned that wheat, and specifically wheat gluten, triggers a certain immune response in autistic children, and particularly people with gastrointestinal problems. This then creates myriads of symptoms commonly linked to autism.

After comparing the effects of gluten consumption in children with autism both with and without gastrointestinal problems to their unaffected siblings and age-matched healthy controls, the team learned that the autistic children had remarkable higher levels of the IgG antibody, which is known to target a gluten protein called gliadin. And in accordancewith the way this antibody functions, many think that high levels of it can also interrupt the  proper neurological function.

“It has been theorized that when the immune system forms antibodies against gliadin, these antibodies cross react with self-structures within the nervous system,” writes Sayer Ji for about the process. “Known as molecular mimicry, this breakdown of immunological self-tolerance can contribute to a wide range of neurological problems including neuropathy, ataxia, seizures, and neurobehavioral changes including mania, schizophrenia and autism.”

“Anti-gliadin antibodies are therefore a possible cause of autoimmune neurological damage,” he adds. Simply put, a lot of the symptoms shown by those who are diagnosed with autism can be cause by an antibody response brought about by being exposed to wheat gluten. Regardless of whether or not the blood markers of actual Celiac disease can be found, wheat gluten seems to greatly raise levels of this anti-gliadin antibody.

“A subset of children with autism displays increased immune reactivity to gluten, the mechanism of which appears to be distinct from that in Celiac disease,” wrote the authors in their conclusion. “The increased anti-gliadin antibody response and its association with GI symptoms points to a potential mechanism involving immunologic and/or intestinal permeability abnormalities in affected children.”

Gluten Free Handbook

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Posted by Chloe Boggs - November 13, 2013 at 3:01 pm

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Gluten antibodies and Celiac Disease question?

Question by Badriya: Gluten antibodies and Celiac Disease question?
I’m just wondering about the process of being diagnosed with CD. I know a blood test is usually done first to check for antibodies to gluten. If found, I’ve read they do a biopsy. My question…why do the biopsy? What other condition would produce antibodies to gluten? And if there are any, wouldn’t the treatment be the same? Just trying to avoid an unnecessary procedure – if possible!


Best answer:

Answer by Glutenfreegirl
Hi! I hope I can help.
Sadly there are several reasons the ENDOSCOPY with biopsy (be sure its an endo, not a colonoscopy) is the gold standard.
For one, some people with Celiac are IGG and IGA deficient. Those are only two of the antibodies they test for in Celiac. But if you don’t make those antibodies, you will ALWAYS test negative for Celiac in blood tests yet you still have it.

Secondly, other common allergies can cause IGG and IGA levels to go up. Those antibodies just show that your body is reacting wrong to something–could be an allergy, could be an intolerance or Celiac Disease.

Thirdly, labs can be wrong! They not do the right test, they can do it wrong, or the patient may not have eaten enough gluten to make the test right (if u have Celiac u have to eat gluten for the blood test or endoscopy to be right so they can see the damage.)

The endoscopy is the best way bc it allows the doc (who needs to be an EXPERIENCED GI with celiac understanding). to see how much damage is done, or if there could be other reasons than Celiac for your issues.

That being said, not every Celiac has a positive diagnosis at all! I mean, some ppl do not have access to such tests nor can they afford it, so they do the elimination diet and self diagnose themselves Celiac (not recommended) or they do genetic testing. Genetic testing is fairly accurate but it only tells u IF you carry the genes for Celiac, not whether u actually have an active case or how much damage is done.

I was diagnosed by blood work only and chose to avoid the scope for financial reasons and bc of pregnancy or other issues. The blood tests were positive for me and the diet works so that’s all the answer I need!

I hope that helps! feel free to email me for more help or use these links!

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Gluten Free Handbook

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Posted by GlutenFree - October 9, 2012 at 1:20 pm

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